Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold
A novel convergent synthetic strategy for the construction of multicomponent Electronics self-adjuvanting lipopeptide vaccines was developed.A tetraalkyne-functionalized glucose derivative and lipidated Fmoc-lysine were prepared by novel efficient and convenient syntheses.The carbohydrate building block was coupled to the self-adjuvanting lipidic m